{"id":4558,"date":"2026-01-25T19:15:32","date_gmt":"2026-01-25T11:15:32","guid":{"rendered":"https:\/\/ieohs.nycu.edu.tw\/?p=4558"},"modified":"2026-01-25T19:15:35","modified_gmt":"2026-01-25T11:15:35","slug":"4558","status":"publish","type":"post","link":"https:\/\/ieohs.nycu.edu.tw\/?p=4558","title":{"rendered":""},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"189\" height=\"260\" src=\"https:\/\/ieohs.nycu.edu.tw\/wp-content\/uploads\/2026\/01\/image-1.png\" alt=\"\" class=\"wp-image-4561\"\/><figcaption class=\"wp-element-caption\">\u674e\u5ba5\u8431 Yu-Hsuan, Lee<\/figcaption><\/figure>\n\n\n\n<p><strong><u>CURRENT POSITION<\/u><\/strong><\/p>\n\n\n\n<p>Associate Professor, Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan<\/p>\n\n\n\n<p><strong><u>ADDRESS<\/u><\/strong><\/p>\n\n\n\n<p>Room 303, Medical Building II<br>No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan<\/p>\n\n\n\n<p><strong><u>EDUCATION<\/u><\/strong><\/p>\n\n\n\n<p>Ph.D.<\/p>\n\n\n\n<p>2010-2015<\/p>\n\n\n\n<p>Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan<\/p>\n\n\n\n<p>M.S.<\/p>\n\n\n\n<p>2006-2008<\/p>\n\n\n\n<p>Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan<\/p>\n\n\n\n<p>B.S<\/p>\n\n\n\n<p>2002-2006<\/p>\n\n\n\n<p>Department of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan<\/p>\n\n\n\n<p><strong><u>AWARDS and HONORS<\/u><\/strong><\/p>\n\n\n\n<ul>\n<li>Travel Award, EMBO conference-Structure and function of the endoplasmic reticulum,<strong> <\/strong>Girona, Spain. 23-27 Oct, 2016.<\/li>\n\n\n\n<li>Innovative BioDesign Award, National Cheng Kung University, Tainan, Taiwan. 28 Jun, 2017<\/li>\n\n\n\n<li>Second place in Startup Competition, National Cheng Kung University, Tainan, Taiwan. 6 Jan, 2018<\/li>\n\n\n\n<li>Best Poster Award. The 34th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. 23-24 Mar, 2019.<\/li>\n\n\n\n<li>Executive Secretary. 1<sup>st<\/sup> winter camp congress of the Taiwan Society of Toxicology. 26-28 Jan, 2019.<\/li>\n\n\n\n<li>MOST Research Grants (Rewarding Outstanding Talent) 2021<\/li>\n\n\n\n<li><strong>Best Poster Award<\/strong>. The 37<sup>th <\/sup>Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. 18-19 Mar, 2023<\/li>\n\n\n\n<li><strong>Outstanding Paper Award<\/strong>. Chinese Society of Toxicology 9th National Youth Science and Technology Conference and 2nd Academic Conference on Biotechnology Drug Toxicology and Safety Evaluation Committee, Xiamen 29-31 Oct, 2023<\/li>\n\n\n\n<li>MOST Research Grants (Rewarding Outstanding Talent) 2024<\/li>\n\n\n\n<li>Hwa Ren Youth Chair Professor Award 2025<\/li>\n<\/ul>\n\n\n\n<p><strong><u>MEMBERSHIPS<\/u><\/strong><\/p>\n\n\n\n<p>Deputy convener of Academic Technology Committee in Toxicology Society of Taiwan (TSTA), (2022-present)<br>Member of Toxicology Society of Taiwan (TSTA), (2017-present)<\/p>\n\n\n\n<p>Member of Taiwan Nanomedicine Society, (2019-present)<\/p>\n\n\n\n<p><strong><u>SERVICE<\/u><\/strong><\/p>\n\n\n\n<p><strong>Current<\/strong><\/p>\n\n\n\n<p>Associate Professor, Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University (2025\/08-present)<\/p>\n\n\n\n<p><strong>Past<\/strong><\/p>\n\n\n\n<p>Associate Professor, Department of Cosmeceutics, China Medical University (2023\/08-2025\/07)<br>Assistant Professor, Department of Cosmeceutics, China Medical University (2019\/08-2023\/07)&nbsp;<\/p>\n\n\n\n<p>Project Assistant Professor, Department of Food Safety \/ Hygiene and Risk Management, College of Medicine, National Cheng Kung University (2017\/08-2019\/07)<\/p>\n\n\n\n<p>Post-doctoral Fellow, Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University (2015\/08-2017\/07)<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong><u>Professional and Research Experience<\/u><\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Environmental toxicology, Research on Health Effects of Emerging Contaminants, Skin immunology, Nanomedcine \/ Nanotoxicology, Natural compounds prevent allergic contact dermatitis<\/p>\n\n\n\n<p><strong><u>PUBLICATIONS<\/u><\/strong><\/p>\n\n\n\n<ul>\n<li>C-C Chang, S-C Fan, Y-J Wang, J-W Ping, Y-H Su, J-C YANG, Y-X Chan, Y-X YANG,<strong><u> Y-H Lee<\/u><\/strong>, C-C Chang, C-H Lin, T-Y Juang *Hyperbranched Polymer Dots Enhance Hair Follicle Regeneration via Wnt\/\u03b2-Catenin Activation: A Drug-Free Nanozyme-Based Approach to Hair Growth Therapy. <strong><em>Biomedicine &amp; Pharmacotherapy<\/em><\/strong> 188, 118196 (2025) (S.C.I. Impact factor:&nbsp;<strong>7.5.<\/strong> Subject Category: 19\/352=5.4%&nbsp;in Pharmacology &amp; Pharmacy, JCR 2024)<\/li>\n\n\n\n<li><strong><u>Y-H Lee<\/u><\/strong>, C-M Zheng, Y-J Wang, Y-L Wang and H-W Chiu<strong>*<\/strong>. Effects of microplastics and nanoplastics on the kidney and cardiovascular system. <strong><em>Nature Reviews Nephrology<\/em><\/strong> 21, 585\u2013596 (2025) (S.C.I. Impact factor: <strong>39.8<\/strong>, 2\/133=1.5% in Urology &amp; Nephrology, JCR 2024) (<strong>First author<\/strong>)<\/li>\n\n\n\n<li>Y-L Wang<sup>#<\/sup>, Y-C Lin<sup>#<\/sup>, W-C Liu, <strong><u>Y-H Lee<sup>*<\/sup> <\/u><\/strong>and H-W Chiu<sup>*<\/sup>. Air pollution and its impacts on health: Focus on microplastics and nanoplastics. <strong><em>Ecotoxicology and Environmental Safety<\/em><\/strong> 299, 118402 (2025) (S.C.I. Impact factor: <strong>6.1<\/strong>. Subject Category: 10\/106=9.4% in Toxicology, JCR 2024) (<strong>Corresponding author<\/strong>)<\/li>\n\n\n\n<li>C-C Chang, H-M Lao, S-C Fan, Y-H Tu, J-C Siew, K-C Ma, <strong><u>Y-H Lee<\/u><\/strong>, H-M Chiang, C-C Chang, T-Y Juang *. Bioactive hyperbranched polymer dot combined laser-induced optical breakdown for accelerating wound repair and regeneration in a nude mice mode. <strong><em>Materials Advances<\/em><\/strong> 6(10):3185-3202 (2025) (S.C.I. Impact factor: <strong>4.7.<\/strong> Subject Category: 207\/462=44.8% in Materials Science, Multidisciplinary, JCR 2024)<\/li>\n\n\n\n<li>H-W Chiu, C-W Chu, C-Ca Huan, Z-C Chia, Y-L Wang, <strong><u>Y-H Lee*<\/u><\/strong>. Polystyrene microplastics induce hepatic lipid metabolism and energy disorder by upregulating the NR4A1-AMPK signaling pathway.<strong><em> Environmental Pollution<\/em><\/strong>&nbsp;369, 125850&nbsp;(2025).&nbsp;(S.C.I. Impact factor: <strong>7.3<\/strong>. Subject Category: 46\/374=12.3% in Environmental Sciences, JCR 2024) (<strong>Corresponding author)<\/strong><\/li>\n\n\n\n<li>Y-H Cheng, H-I. Wu, Y-Y Chen, <strong><u>Y-H Lee<\/u><\/strong>, B-J Wang* and Y-J Wang*. Adverse outcome pathway-based approach to reveal the mechanisms of skin sensitization and long-term aging effects of chlorothalonil. <strong><em>Journal of Hazardous Materials<\/em><\/strong> 476, 135176 (2024). (S.C.I. Impact factor: <strong>11.3<\/strong>. Subject Category: 19\/374=5.1% in Environmental Sciences, JCR 2024)<\/li>\n\n\n\n<li>B-J Wang, Y-Y Chen, H-H Chang, R-J Chen, Y-J Wang* and<strong><u> Y-H Lee*<\/u><\/strong>. Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury. <strong><em>Particle and Fibre Toxicology<\/em><\/strong>. 21, 9 (2024). (S.C.I. Impact factor: <strong>8.2<\/strong>. Subject Category: 5\/106=4.7% in Toxicology, JCR 2024) <strong>(Corresponding author)<\/strong> <a><\/a><\/li>\n\n\n\n<li>*. Oxidative stress and potential effects of metal nanoparticles: a review of biocompatibility and toxicity concerns.&nbsp;<strong><em>Environmental Pollution<\/em><\/strong>&nbsp;346, 123617&nbsp;(2024)&nbsp;(S.C.I. Impact factor: <strong>7.3<\/strong>. Subject Category: 46\/374=12.3% in Environmental Sciences, JCR 2024)<\/li>\n\n\n\n<li>Y-L Wang<sup>#<\/sup>, C C-Y Huang, C-M Zheng, W-C Liu, <strong><u>Y-H Lee<sup>#<\/sup><\/u><\/strong>&nbsp;and H-W Chiu*. Polystyrene microplastic-induced extracellular vesicles cause kidney-related effects in the crosstalk between tubular cells and fibroblasts.&nbsp;<strong><em>Ecotoxicology and Environmental Safety<\/em><\/strong>&nbsp;273, 116098 (2024) (S.C.I. Impact factor: <strong>6.1<\/strong>. Subject Category: 10\/106=9.4% in Toxicology, JCR 2024)<strong> (co-First author)<\/strong><\/li>\n\n\n\n<li>H-J Huang<sup>#<\/sup>, <strong><u>Y-H Lee<\/u><\/strong>, L-C Sung, Y-J Chen, Y-J Chiu, H-W Chiu<sup>#<\/sup> and C-M Zheng*. Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor. <strong><em>Computational and Structural Biotechnology Journal<\/em><\/strong> 21, 3490\u20133502 (2023) (S.C.I. Impact factor: <strong>4.1<\/strong>. Subject Category: 104\/319=32.6% in Biochemistry &amp; Molecular Biology, JCR 2024)<\/li>\n\n\n\n<li>W-C Liu, H-W Chiu, C-L Chou, Y-J Chiu and <strong><u>Y-H Lee*<\/u><\/strong>. Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2\/CENPE axis. <strong><em>Environmental Pollution<\/em><\/strong> 318, 120871 (2023). (S.C.I. Impact factor: <strong>7.3<\/strong>. Subject Category: 46\/374=12.3% in Environmental Sciences, JCR 2024) (<strong>Corresponding author)<\/strong><\/li>\n\n\n\n<li>C-M Zheng, K-C Lu, Y-J Chen, C-Y Li, <strong><u>Y-H Lee*<\/u><\/strong> and H-W Chiu*. Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy. <strong><em>Biomedicine &amp; Pharmacotherapy<\/em><\/strong> 154, 113565 (2022). (S.C.I. Impact factor:&nbsp;<strong>7.5.<\/strong> Subject Category: 19\/352=5.4%&nbsp;in Pharmacology &amp; Pharmacy, JCR 2024) (<strong>Corresponding author)<\/strong><\/li>\n\n\n\n<li>Z-Y Chen, Y-C Yang, B-J Wang, F-Y Cheng, Y-L Lee, <strong><u>Y-H Lee*<\/u><\/strong> and Y-J Wang<strong>*<\/strong>. Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae. <strong><em>Ecotoxicology and Environmental Safety <\/em><\/strong>243, 113967 (2022). (S.C.I. Impact factor: <strong>6.1<\/strong>. Subject Category: 10\/106=9.4% in Toxicology, JCR 2024)(<strong>Corresponding author)<\/strong> H-J Huang, <strong><u>Y-H Lee<\/u><\/strong>, C-L Chou, C-M Zheng*and H-W Chiu*. Investigation of potential descriptors of chemical compounds on prevention of nephrotoxicity via QSAR approach. <strong><em>Computational and Structural Biotechnology Journal<\/em><\/strong> 20,1876-1884&nbsp;(2022). (S.C.I. Impact factor: <strong>4.1<\/strong>. Subject Category: 104\/319=32.6% in Biochemistry &amp; Molecular Biology, JCR 2024).<\/li>\n\n\n\n<li>W-C Liu<sup>#<\/sup>, H-C Chuang, C-L Chou, <strong>Y-H Lee<\/strong>, Y-J Chiu, Y-L Wang<sup>#<\/sup> and H-W Chiu*. Cigarette smoke exposure increases glucose-6-phosphate dehydrogenase, autophagy, fibrosis and senescence in kidney cells <em>in vitro<\/em> and <em>in vivo<\/em>. <strong><em>Oxidative Medicine and Cellular Longevity <\/em><\/strong>2022, 5696686(2022).<\/li>\n\n\n\n<li>B-H Mao<sup>#<\/sup>, Y-K Luo, B-J Wang, C-W Chen, F-Y Cheng, <strong>Y-H Lee<sup>#<\/sup><\/strong>, S-J Yan*, Y-J Wang*. Use of an In silico Knowledge Discovery Approach to Determine Mechanistic Studies of Silver Nanoparticles-induced Toxicity from In vitro to In vivo.<strong><em> Particle and Fibre Toxicology<\/em><\/strong>. 19, 6 (2022). (S.C.I. Impact factor: <strong>8.2<\/strong>. Subject Category: 5\/106=4.7% in Toxicology, JCR 2024)<strong> (co-First author)<\/strong><\/li>\n\n\n\n<li>Y-Y Chen<strong><sup>#<\/sup><\/strong>, <strong>Y-H Lee<sup>#<\/sup><\/strong>, B-J Wang, R-J Chen, Y-J Wang. Skin Damage Induced by Zinc Oxide Nanoparticles Combined with UVB is Mediated by Activating Cell Pyroptosis via the NLRP3 Inflammasome-Autophagy-Exosomal Pathway. <strong><em>Particle and Fibre Toxicology<\/em><\/strong>. 19, 2 (2022). (S.C.I. Impact factor: <strong>8.2<\/strong>. Subject Category: 5\/106=4.7% in Toxicology, JCR 2024)<strong> (co-First author)<\/strong><\/li>\n\n\n\n<li>Y-L Wang<sup>#<\/sup>, <strong>Y-H Lee<\/strong>, Y-H Hsu, I-J Chiu, C C-Y Huang,&nbsp;C-C Huang, Z-C Chia,&nbsp;C-P Lee, Y-F Lin<sup>#<\/sup>&nbsp;and H-W Chiu*.&nbsp;The kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells HK-2 and male C57BL\/6 mice.&nbsp;<strong><em>Environmental Health Perspectives<\/em><\/strong>&nbsp;129(5), 57003 (2021). (S.C.I. Impact factor: 9.8. Subject Category: 3\/106=2.8% in Toxicology, JCR 2024)<\/li>\n\n\n\n<li>Y-L Wang, C-M Zheng, <strong>Y-H Lee<\/strong>, Y-Y Cheng, Y-F Lin and H-W Chiu*. Micro- and nanosized substances cause different autophagy-related responses.&nbsp;<strong><em>International Journal of Molecular Sciences&nbsp;<\/em><\/strong>22, 4787 (2021). (S.C.I. Impact factor: <strong>4.9<\/strong>. Subject Category: 72\/319=22.6% in Biochemistry &amp; Molecular Biology, JCR 2024)<\/li>\n\n\n\n<li>H-J Huang,&nbsp;<strong>Y-H Lee<\/strong>,&nbsp;Y-H Hsu, C-T Liao, Y-F Lin* and&nbsp;H-W Chiu*. Current strategies in assessment of nanotoxicity: Alternatives to&nbsp;<em>in vivo<\/em>&nbsp;animal testing.&nbsp;<strong><em>International Journal of Molecular Sciences&nbsp;<\/em><\/strong>22, 4216 (2021). (S.C.I. Impact factor: <strong>4.9<\/strong>. Subject Category: 72\/319=22.6% in Biochemistry &amp; Molecular Biology, JCR 2024)<\/li>\n\n\n\n<li>Y-H Hsu<sup>#<\/sup>, C-M Zheng, C-L Chou, Y-J Chen, <strong>Y-H Lee<sup>#<\/sup><\/strong>, Y-F Lin*, H-W Chiu*. Therapeutic effect of endothelin-converting enzyme inhibitor on chronic kidney disease through the inhibition of endoplasmic reticulum stress and the NLRP3 inflammasome. <strong><em>Biomedicines<\/em><\/strong> 9, 398 (2021). (S.C.I. Impact factor: <strong>3.9.<\/strong> Subject Category: 88\/352=25.0% in Pharmacology &amp; Pharmacy, JCR 2024) <strong>(co-First author)<\/strong><\/li>\n\n\n\n<li>R\u2011J Chen<sup>#<\/sup>, C-C Huang, R Pranata, <strong>Y\u2011H Lee<sup>#<\/sup><\/strong>, Y-Y Chen, Y-H Wu*, Y\u2011J Wang*. Modulation of innate immune toxicity by silver nanoparticle exposure and the preventive effects of pterostilbene.<strong><em> International Journal of Molecular Sciences<\/em><\/strong> 22, 2536 (2021). (S.C.I. Impact factor: <strong>4.9<\/strong>. Subject Category: 72\/319=22.6% in Biochemistry &amp; Molecular Biology, JCR 2024) <strong>(co-First author)<\/strong><\/li>\n\n\n\n<li>R\u2011J Chen<sup>#<\/sup>, <strong>Y\u2011H Lee<sup>#<\/sup><\/strong>, T\u2011H Chen, Y\u2011Y Chen, Y\u2011L Yeh, C\u2011P Chang, C\u2011C Huang, H-R Guo*, Y\u2011J Wang*. Carbon monoxide\u2011triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes. <strong><em>Archives of Toxicology<\/em><\/strong> 95(4):1141-1159 (2021). (<a>S.C.I. Impact factor: <strong>6.9<\/strong> Subject Category:8\/106=7.5% in Toxicology, JCR 202<\/a>4).<strong> (co-First author)<\/strong><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>CURRENT POSITION Associate Professor, Institute of Envi &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/ieohs.nycu.edu.tw\/?p=4558\">  \u95b1\u8b80\u5168\u6587 &raquo;<\/a><\/p>\n","protected":false},"author":10,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":""},"categories":[2],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>- NYCU_IEOHS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ieohs.nycu.edu.tw\/?p=4558\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"- NYCU_IEOHS\" \/>\n<meta property=\"og:description\" content=\"CURRENT POSITION Associate Professor, Institute of Envi &hellip; 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