李宥萱 Yu-Hsuan, Lee

CURRENT POSITION

Associate Professor, Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

ADDRESS

Room 303, Medical Building II
No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan

EDUCATION

Ph.D.

2010-2015

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan

M.S.

2006-2008

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan

B.S

2002-2006

Department of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan

AWARDS and HONORS

  • Travel Award, EMBO conference-Structure and function of the endoplasmic reticulum, Girona, Spain. 23-27 Oct, 2016.
  • Innovative BioDesign Award, National Cheng Kung University, Tainan, Taiwan. 28 Jun, 2017
  • Second place in Startup Competition, National Cheng Kung University, Tainan, Taiwan. 6 Jan, 2018
  • Best Poster Award. The 34th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. 23-24 Mar, 2019.
  • Executive Secretary. 1st winter camp congress of the Taiwan Society of Toxicology. 26-28 Jan, 2019.
  • MOST Research Grants (Rewarding Outstanding Talent) 2021
  • Best Poster Award. The 37th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. 18-19 Mar, 2023
  • Outstanding Paper Award. Chinese Society of Toxicology 9th National Youth Science and Technology Conference and 2nd Academic Conference on Biotechnology Drug Toxicology and Safety Evaluation Committee, Xiamen 29-31 Oct, 2023
  • MOST Research Grants (Rewarding Outstanding Talent) 2024
  • Hwa Ren Youth Chair Professor Award 2025

MEMBERSHIPS

Deputy convener of Academic Technology Committee in Toxicology Society of Taiwan (TSTA), (2022-present)
Member of Toxicology Society of Taiwan (TSTA), (2017-present)

Member of Taiwan Nanomedicine Society, (2019-present)

SERVICE

Current

Associate Professor, Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University (2025/08-present)

Past

Associate Professor, Department of Cosmeceutics, China Medical University (2023/08-2025/07)
Assistant Professor, Department of Cosmeceutics, China Medical University (2019/08-2023/07) 

Project Assistant Professor, Department of Food Safety / Hygiene and Risk Management, College of Medicine, National Cheng Kung University (2017/08-2019/07)

Post-doctoral Fellow, Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University (2015/08-2017/07)

Professional and Research Experience

Environmental toxicology, Research on Health Effects of Emerging Contaminants, Skin immunology, Nanomedcine / Nanotoxicology, Natural compounds prevent allergic contact dermatitis

PUBLICATIONS

  • C-C Chang, S-C Fan, Y-J Wang, J-W Ping, Y-H Su, J-C YANG, Y-X Chan, Y-X YANG, Y-H Lee, C-C Chang, C-H Lin, T-Y Juang *Hyperbranched Polymer Dots Enhance Hair Follicle Regeneration via Wnt/β-Catenin Activation: A Drug-Free Nanozyme-Based Approach to Hair Growth Therapy. Biomedicine & Pharmacotherapy 188, 118196 (2025) (S.C.I. Impact factor: 7.5. Subject Category: 19/352=5.4% in Pharmacology & Pharmacy, JCR 2024)
  • Y-H Lee, C-M Zheng, Y-J Wang, Y-L Wang and H-W Chiu*. Effects of microplastics and nanoplastics on the kidney and cardiovascular system. Nature Reviews Nephrology 21, 585–596 (2025) (S.C.I. Impact factor: 39.8, 2/133=1.5% in Urology & Nephrology, JCR 2024) (First author)
  • Y-L Wang#, Y-C Lin#, W-C Liu, Y-H Lee* and H-W Chiu*. Air pollution and its impacts on health: Focus on microplastics and nanoplastics. Ecotoxicology and Environmental Safety 299, 118402 (2025) (S.C.I. Impact factor: 6.1. Subject Category: 10/106=9.4% in Toxicology, JCR 2024) (Corresponding author)
  • C-C Chang, H-M Lao, S-C Fan, Y-H Tu, J-C Siew, K-C Ma, Y-H Lee, H-M Chiang, C-C Chang, T-Y Juang *. Bioactive hyperbranched polymer dot combined laser-induced optical breakdown for accelerating wound repair and regeneration in a nude mice mode. Materials Advances 6(10):3185-3202 (2025) (S.C.I. Impact factor: 4.7. Subject Category: 207/462=44.8% in Materials Science, Multidisciplinary, JCR 2024)
  • H-W Chiu, C-W Chu, C-Ca Huan, Z-C Chia, Y-L Wang, Y-H Lee*. Polystyrene microplastics induce hepatic lipid metabolism and energy disorder by upregulating the NR4A1-AMPK signaling pathway. Environmental Pollution 369, 125850 (2025). (S.C.I. Impact factor: 7.3. Subject Category: 46/374=12.3% in Environmental Sciences, JCR 2024) (Corresponding author)
  • Y-H Cheng, H-I. Wu, Y-Y Chen, Y-H Lee, B-J Wang* and Y-J Wang*. Adverse outcome pathway-based approach to reveal the mechanisms of skin sensitization and long-term aging effects of chlorothalonil. Journal of Hazardous Materials 476, 135176 (2024). (S.C.I. Impact factor: 11.3. Subject Category: 19/374=5.1% in Environmental Sciences, JCR 2024)
  • B-J Wang, Y-Y Chen, H-H Chang, R-J Chen, Y-J Wang* and Y-H Lee*. Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury. Particle and Fibre Toxicology. 21, 9 (2024). (S.C.I. Impact factor: 8.2. Subject Category: 5/106=4.7% in Toxicology, JCR 2024) (Corresponding author)
  • *. Oxidative stress and potential effects of metal nanoparticles: a review of biocompatibility and toxicity concerns. Environmental Pollution 346, 123617 (2024) (S.C.I. Impact factor: 7.3. Subject Category: 46/374=12.3% in Environmental Sciences, JCR 2024)
  • Y-L Wang#, C C-Y Huang, C-M Zheng, W-C Liu, Y-H Lee# and H-W Chiu*. Polystyrene microplastic-induced extracellular vesicles cause kidney-related effects in the crosstalk between tubular cells and fibroblasts. Ecotoxicology and Environmental Safety 273, 116098 (2024) (S.C.I. Impact factor: 6.1. Subject Category: 10/106=9.4% in Toxicology, JCR 2024) (co-First author)
  • H-J Huang#, Y-H Lee, L-C Sung, Y-J Chen, Y-J Chiu, H-W Chiu# and C-M Zheng*. Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor. Computational and Structural Biotechnology Journal 21, 3490–3502 (2023) (S.C.I. Impact factor: 4.1. Subject Category: 104/319=32.6% in Biochemistry & Molecular Biology, JCR 2024)
  • W-C Liu, H-W Chiu, C-L Chou, Y-J Chiu and Y-H Lee*. Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis. Environmental Pollution 318, 120871 (2023). (S.C.I. Impact factor: 7.3. Subject Category: 46/374=12.3% in Environmental Sciences, JCR 2024) (Corresponding author)
  • C-M Zheng, K-C Lu, Y-J Chen, C-Y Li, Y-H Lee* and H-W Chiu*. Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy. Biomedicine & Pharmacotherapy 154, 113565 (2022). (S.C.I. Impact factor: 7.5. Subject Category: 19/352=5.4% in Pharmacology & Pharmacy, JCR 2024) (Corresponding author)
  • Z-Y Chen, Y-C Yang, B-J Wang, F-Y Cheng, Y-L Lee, Y-H Lee* and Y-J Wang*. Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae. Ecotoxicology and Environmental Safety 243, 113967 (2022). (S.C.I. Impact factor: 6.1. Subject Category: 10/106=9.4% in Toxicology, JCR 2024)(Corresponding author) H-J Huang, Y-H Lee, C-L Chou, C-M Zheng*and H-W Chiu*. Investigation of potential descriptors of chemical compounds on prevention of nephrotoxicity via QSAR approach. Computational and Structural Biotechnology Journal 20,1876-1884 (2022). (S.C.I. Impact factor: 4.1. Subject Category: 104/319=32.6% in Biochemistry & Molecular Biology, JCR 2024).
  • W-C Liu#, H-C Chuang, C-L Chou, Y-H Lee, Y-J Chiu, Y-L Wang# and H-W Chiu*. Cigarette smoke exposure increases glucose-6-phosphate dehydrogenase, autophagy, fibrosis and senescence in kidney cells in vitro and in vivo. Oxidative Medicine and Cellular Longevity 2022, 5696686(2022).
  • B-H Mao#, Y-K Luo, B-J Wang, C-W Chen, F-Y Cheng, Y-H Lee#, S-J Yan*, Y-J Wang*. Use of an In silico Knowledge Discovery Approach to Determine Mechanistic Studies of Silver Nanoparticles-induced Toxicity from In vitro to In vivo. Particle and Fibre Toxicology. 19, 6 (2022). (S.C.I. Impact factor: 8.2. Subject Category: 5/106=4.7% in Toxicology, JCR 2024) (co-First author)
  • Y-Y Chen#, Y-H Lee#, B-J Wang, R-J Chen, Y-J Wang. Skin Damage Induced by Zinc Oxide Nanoparticles Combined with UVB is Mediated by Activating Cell Pyroptosis via the NLRP3 Inflammasome-Autophagy-Exosomal Pathway. Particle and Fibre Toxicology. 19, 2 (2022). (S.C.I. Impact factor: 8.2. Subject Category: 5/106=4.7% in Toxicology, JCR 2024) (co-First author)
  • Y-L Wang#, Y-H Lee, Y-H Hsu, I-J Chiu, C C-Y Huang, C-C Huang, Z-C Chia, C-P Lee, Y-F Lin# and H-W Chiu*. The kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells HK-2 and male C57BL/6 mice. Environmental Health Perspectives 129(5), 57003 (2021). (S.C.I. Impact factor: 9.8. Subject Category: 3/106=2.8% in Toxicology, JCR 2024)
  • Y-L Wang, C-M Zheng, Y-H Lee, Y-Y Cheng, Y-F Lin and H-W Chiu*. Micro- and nanosized substances cause different autophagy-related responses. International Journal of Molecular Sciences 22, 4787 (2021). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024)
  • H-J Huang, Y-H Lee, Y-H Hsu, C-T Liao, Y-F Lin* and H-W Chiu*. Current strategies in assessment of nanotoxicity: Alternatives to in vivo animal testing. International Journal of Molecular Sciences 22, 4216 (2021). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024)
  • Y-H Hsu#, C-M Zheng, C-L Chou, Y-J Chen, Y-H Lee#, Y-F Lin*, H-W Chiu*. Therapeutic effect of endothelin-converting enzyme inhibitor on chronic kidney disease through the inhibition of endoplasmic reticulum stress and the NLRP3 inflammasome. Biomedicines 9, 398 (2021). (S.C.I. Impact factor: 3.9. Subject Category: 88/352=25.0% in Pharmacology & Pharmacy, JCR 2024) (co-First author)
  • R‑J Chen#, C-C Huang, R Pranata, Y‑H Lee#, Y-Y Chen, Y-H Wu*, Y‑J Wang*. Modulation of innate immune toxicity by silver nanoparticle exposure and the preventive effects of pterostilbene. International Journal of Molecular Sciences 22, 2536 (2021). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024) (co-First author)
  • R‑J Chen#, Y‑H Lee#, T‑H Chen, Y‑Y Chen, Y‑L Yeh, C‑P Chang, C‑C Huang, H-R Guo*, Y‑J Wang*. Carbon monoxide‑triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes. Archives of Toxicology 95(4):1141-1159 (2021). (S.C.I. Impact factor: 6.9 Subject Category:8/106=7.5% in Toxicology, JCR 2024). (co-First author)

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