CURRENT POSITION

Associate Professor, Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

ADDRESS

Room 303, Medical Building II
No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan

EDUCATION

Ph.D.

2010-2015

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan

M.S.

2006-2008

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan

B.S

2002-2006

Department of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan

AWARDS and HONORS

• Travel Award, EMBO conference-Structure and function of the endoplasmic reticulum, Girona, Spain. 23-27 Oct, 2016.
• Innovative BioDesign Award, National Cheng Kung University, Tainan, Taiwan. 28 Jun, 2017
• Second place in Startup Competition, National Cheng Kung University, Tainan, Taiwan. 6 Jan, 2018
• Best Poster Award. The 34th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. 23-24 Mar, 2019.
• Executive Secretary. 1^st winter camp congress of the Taiwan Society of Toxicology. 26-28 Jan, 2019.
• MOST Research Grants (Rewarding Outstanding Talent) 2021
• Best Poster Award. The 37^th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. 18-19 Mar, 2023
• Outstanding Paper Award. Chinese Society of Toxicology 9th National Youth Science and Technology Conference and 2nd Academic Conference on Biotechnology Drug Toxicology and Safety Evaluation Committee, Xiamen 29-31 Oct, 2023
• MOST Research Grants (Rewarding Outstanding Talent) 2024
• Hwa Ren Youth Chair Professor Award 2025

MEMBERSHIPS

Deputy convener of Academic Technology Committee in Toxicology Society of Taiwan (TSTA), (2022-present)
Member of Toxicology Society of Taiwan (TSTA), (2017-present)

Member of Taiwan Nanomedicine Society, (2019-present)

SERVICE

Current

Associate Professor, Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University (2025/08-present)

Past

Associate Professor, Department of Cosmeceutics, China Medical University (2023/08-2025/07)
Assistant Professor, Department of Cosmeceutics, China Medical University (2019/08-2023/07) 

Project Assistant Professor, Department of Food Safety / Hygiene and Risk Management, College of Medicine, National Cheng Kung University (2017/08-2019/07)

Post-doctoral Fellow, Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University (2015/08-2017/07)

Environmental toxicology, Research on Health Effects of Emerging Contaminants, Skin immunology, Nanomedcine / Nanotoxicology, Natural compounds prevent allergic contact dermatitis

PUBLICATIONS

• C-C Chang, S-C Fan, Y-J Wang, J-W Ping, Y-H Su, J-C YANG, Y-X Chan, Y-X YANG, Y-H Lee, C-C Chang, C-H Lin, T-Y Juang *Hyperbranched Polymer Dots Enhance Hair Follicle Regeneration via Wnt/β-Catenin Activation: A Drug-Free Nanozyme-Based Approach to Hair Growth Therapy. Biomedicine & Pharmacotherapy 188, 118196 (2025) (S.C.I. Impact factor: 7.5. Subject Category: 19/352=5.4% in Pharmacology & Pharmacy, JCR 2024)
• Y-H Lee, C-M Zheng, Y-J Wang, Y-L Wang and H-W Chiu*. Effects of microplastics and nanoplastics on the kidney and cardiovascular system. Nature Reviews Nephrology 21, 585–596 (2025) (S.C.I. Impact factor: 39.8, 2/133=1.5% in Urology & Nephrology, JCR 2024) (First author)
• Y-L Wang^#, Y-C Lin^#, W-C Liu, Y-H Lee^* and H-W Chiu^*. Air pollution and its impacts on health: Focus on microplastics and nanoplastics. Ecotoxicology and Environmental Safety 299, 118402 (2025) (S.C.I. Impact factor: 6.1. Subject Category: 10/106=9.4% in Toxicology, JCR 2024) (Corresponding author)
• C-C Chang, H-M Lao, S-C Fan, Y-H Tu, J-C Siew, K-C Ma, Y-H Lee, H-M Chiang, C-C Chang, T-Y Juang *. Bioactive hyperbranched polymer dot combined laser-induced optical breakdown for accelerating wound repair and regeneration in a nude mice mode. Materials Advances 6(10):3185-3202 (2025) (S.C.I. Impact factor: 4.7. Subject Category: 207/462=44.8% in Materials Science, Multidisciplinary, JCR 2024)
• H-W Chiu, C-W Chu, C-Ca Huan, Z-C Chia, Y-L Wang, Y-H Lee*. Polystyrene microplastics induce hepatic lipid metabolism and energy disorder by upregulating the NR4A1-AMPK signaling pathway. Environmental Pollution 369, 125850 (2025). (S.C.I. Impact factor: 7.3. Subject Category: 46/374=12.3% in Environmental Sciences, JCR 2024) (Corresponding author)
• Y-H Cheng, H-I. Wu, Y-Y Chen, Y-H Lee, B-J Wang* and Y-J Wang*. Adverse outcome pathway-based approach to reveal the mechanisms of skin sensitization and long-term aging effects of chlorothalonil. Journal of Hazardous Materials 476, 135176 (2024). (S.C.I. Impact factor: 11.3. Subject Category: 19/374=5.1% in Environmental Sciences, JCR 2024)
• B-J Wang, Y-Y Chen, H-H Chang, R-J Chen, Y-J Wang* and Y-H Lee*. Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury. Particle and Fibre Toxicology. 21, 9 (2024). (S.C.I. Impact factor: 8.2. Subject Category: 5/106=4.7% in Toxicology, JCR 2024) (Corresponding author)
• *. Oxidative stress and potential effects of metal nanoparticles: a review of biocompatibility and toxicity concerns. Environmental Pollution 346, 123617 (2024) (S.C.I. Impact factor: 7.3. Subject Category: 46/374=12.3% in Environmental Sciences, JCR 2024)
• Y-L Wang^#, C C-Y Huang, C-M Zheng, W-C Liu, Y-H Lee^# and H-W Chiu*. Polystyrene microplastic-induced extracellular vesicles cause kidney-related effects in the crosstalk between tubular cells and fibroblasts. Ecotoxicology and Environmental Safety 273, 116098 (2024) (S.C.I. Impact factor: 6.1. Subject Category: 10/106=9.4% in Toxicology, JCR 2024) (co-First author)
• H-J Huang^#, Y-H Lee, L-C Sung, Y-J Chen, Y-J Chiu, H-W Chiu^# and C-M Zheng*. Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor. Computational and Structural Biotechnology Journal 21, 3490–3502 (2023) (S.C.I. Impact factor: 4.1. Subject Category: 104/319=32.6% in Biochemistry & Molecular Biology, JCR 2024)
• W-C Liu, H-W Chiu, C-L Chou, Y-J Chiu and Y-H Lee*. Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis. Environmental Pollution 318, 120871 (2023). (S.C.I. Impact factor: 7.3. Subject Category: 46/374=12.3% in Environmental Sciences, JCR 2024) (Corresponding author)
• C-M Zheng, K-C Lu, Y-J Chen, C-Y Li, Y-H Lee* and H-W Chiu*. Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy. Biomedicine & Pharmacotherapy 154, 113565 (2022). (S.C.I. Impact factor: 7.5. Subject Category: 19/352=5.4% in Pharmacology & Pharmacy, JCR 2024) (Corresponding author)
• Z-Y Chen, Y-C Yang, B-J Wang, F-Y Cheng, Y-L Lee, Y-H Lee* and Y-J Wang*. Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae. Ecotoxicology and Environmental Safety 243, 113967 (2022). (S.C.I. Impact factor: 6.1. Subject Category: 10/106=9.4% in Toxicology, JCR 2024)(Corresponding author) H-J Huang, Y-H Lee, C-L Chou, C-M Zheng*and H-W Chiu*. Investigation of potential descriptors of chemical compounds on prevention of nephrotoxicity via QSAR approach. Computational and Structural Biotechnology Journal 20,1876-1884 (2022). (S.C.I. Impact factor: 4.1. Subject Category: 104/319=32.6% in Biochemistry & Molecular Biology, JCR 2024).
• W-C Liu^#, H-C Chuang, C-L Chou, Y-H Lee, Y-J Chiu, Y-L Wang^# and H-W Chiu*. Cigarette smoke exposure increases glucose-6-phosphate dehydrogenase, autophagy, fibrosis and senescence in kidney cells in vitro and in vivo. Oxidative Medicine and Cellular Longevity 2022, 5696686(2022).
• B-H Mao^#, Y-K Luo, B-J Wang, C-W Chen, F-Y Cheng, Y-H Lee^#, S-J Yan*, Y-J Wang*. Use of an In silico Knowledge Discovery Approach to Determine Mechanistic Studies of Silver Nanoparticles-induced Toxicity from In vitro to In vivo. Particle and Fibre Toxicology. 19, 6 (2022). (S.C.I. Impact factor: 8.2. Subject Category: 5/106=4.7% in Toxicology, JCR 2024) (co-First author)
• Y-Y Chen^#, Y-H Lee^#, B-J Wang, R-J Chen, Y-J Wang. Skin Damage Induced by Zinc Oxide Nanoparticles Combined with UVB is Mediated by Activating Cell Pyroptosis via the NLRP3 Inflammasome-Autophagy-Exosomal Pathway. Particle and Fibre Toxicology. 19, 2 (2022). (S.C.I. Impact factor: 8.2. Subject Category: 5/106=4.7% in Toxicology, JCR 2024) (co-First author)
• Y-L Wang^#, Y-H Lee, Y-H Hsu, I-J Chiu, C C-Y Huang, C-C Huang, Z-C Chia, C-P Lee, Y-F Lin^# and H-W Chiu*. The kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells HK-2 and male C57BL/6 mice. Environmental Health Perspectives 129(5), 57003 (2021). (S.C.I. Impact factor: 9.8. Subject Category: 3/106=2.8% in Toxicology, JCR 2024)
• Y-L Wang, C-M Zheng, Y-H Lee, Y-Y Cheng, Y-F Lin and H-W Chiu*. Micro- and nanosized substances cause different autophagy-related responses. International Journal of Molecular Sciences 22, 4787 (2021). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024)
• H-J Huang, Y-H Lee, Y-H Hsu, C-T Liao, Y-F Lin* and H-W Chiu*. Current strategies in assessment of nanotoxicity: Alternatives to in vivo animal testing. International Journal of Molecular Sciences 22, 4216 (2021). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024)
• Y-H Hsu^#, C-M Zheng, C-L Chou, Y-J Chen, Y-H Lee^#, Y-F Lin*, H-W Chiu*. Therapeutic effect of endothelin-converting enzyme inhibitor on chronic kidney disease through the inhibition of endoplasmic reticulum stress and the NLRP3 inflammasome. Biomedicines 9, 398 (2021). (S.C.I. Impact factor: 3.9. Subject Category: 88/352=25.0% in Pharmacology & Pharmacy, JCR 2024) (co-First author)
• R‑J Chen^#, C-C Huang, R Pranata, Y‑H Lee^#, Y-Y Chen, Y-H Wu*, Y‑J Wang*. Modulation of innate immune toxicity by silver nanoparticle exposure and the preventive effects of pterostilbene. International Journal of Molecular Sciences 22, 2536 (2021). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024) (co-First author)
• R‑J Chen^#, Y‑H Lee^#, T‑H Chen, Y‑Y Chen, Y‑L Yeh, C‑P Chang, C‑C Huang, H-R Guo*, Y‑J Wang*. Carbon monoxide‑triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes. Archives of Toxicology 95(4):1141-1159 (2021). (S.C.I. Impact factor: 6.9 Subject Category:8/106=7.5% in Toxicology, JCR 2024). (co-First author)

李宥萱 副教授

學歷

國立成功大學/環境醫學研究所/博士

國立成功大學/環境醫學研究所/碩士

中山醫學大學/職業安全與衛生學系/學士

技術專長

1. 環境毒理學
2. 皮膚疾病/免疫學
3. 奈米材料應用與安全性評估
4. 細胞生物學

email: Yhlee25@nycu.edu.tw

phone: +886-2-2826-7000 #67323

經歷

服務機關	服務部門／系所	職稱
現職：國立陽明交通大學	環境與職業衛生研究所	副教授
現職：台灣毒物學學會	學術科技委員會	副召集人
中國醫藥大學	藥用化妝品學系	副教授
中國醫藥大學	藥用化妝品學系	助理教授
國立成功大學	食品安全衛生暨風險管理研究所	專案助理教授
國立成功大學	醫學院環境醫學研究所	博士後研究員
國立成功大學	醫學院環境醫學研究所	研究助理

研究方向: 近年來的研究重點在於發炎反應及疾病的預防治療，內容包括空氣中的懸浮微粒、塑膠微粒、六價鉻及奈米粒子等。研究方向著重在發炎反應的調控與皮膚、肝臟、腎臟毒性的相關性、調節細胞增生及死亡方式，並探討氧化壓力及重要訊息傳遞路徑改變等在環境毒物毒性及疾病產生過程的角色。

獲獎紀錄

獲獎紀錄

1.  2014年國立成功大學優秀論文競賽 優勝

2.  2015年國立成功大學優秀論文競賽 優勝

3.  EMBO conference-Structure and function of the endoplasmic              reticulum Travel award, Girona, Spain, 23-27 October, 2016.

4.  2017年 國立成功大學醫療器材創新設計(II) 成果發表競賽 第一名

5.  2018年 國立成功大學精實創業成果發表暨創業競賽 第二名

6.  Best Poster Award. The 34^th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. 23-24 Mar, 2019.

7.  2019 台灣大學生物技術研究中心第35屆生物夏令營-榮獲優秀學員

8.  2021年度科技部研究獎勵 (獎勵特殊優秀人才) -彈性薪資獎勵 MOST Research Grants (Rewarding Outstanding Talent)

9.  Best Poster Award. The 37^th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. 18-19 Mar, 2023.

10.  2023 中國毒理學會第九屆全國青年科技大會暨第二屆生物技術藥物毒理與安全評價委員會學術會議—優秀論文獎

11. 2024年度國科會研究獎勵 (獎勵特殊優秀人才) -彈性薪資獎勵 NSTC Research Grants (Rewarding Outstanding Talent)

代 表 著 作

• C-C Chang, S-C Fan, Y-J Wang, J-W Ping, Y-H Su, J-C YANG, Y-X Chan, Y-X YANG, Y-H Lee, C-C Chang, C-H Lin, T-Y Juang *Hyperbranched Polymer Dots Enhance Hair Follicle Regeneration via Wnt/β-Catenin Activation: A Drug-Free Nanozyme-Based Approach to Hair Growth Therapy. Biomedicine & Pharmacotherapy 188():1-11 (2025) (S.C.I. Impact factor: 7.5. Subject Category: 19/352=5.4% in Pharmacology & Pharmacy, JCR 2024)
• Y-H Lee, C-M Zheng, Y-J Wang, Y-L Wang and H-W Chiu*. Effects of microplastics and nanoplastics on the kidney and cardiovascular system. Nature Reviews Nephrology (In Press) (S.C.I. Impact factor: 39.8, 2/133=1.5% in Urology & Nephrology, JCR 2024) (First author) NSTC 113-2314-B-038-084 and NSTC 113-2314-B-039-044
• Y-L Wang^#, Y-C Lin^#, W-C Liu, Y-H Lee^* and H-W Chiu^*. Air pollution and its impacts on health: Focus on microplastics and nanoplastics. Ecotoxicology and Environmental Safety 299, 118402 (2025) (S.C.I. Impact factor: 6.1. Subject Category: 10/106=9.4% in Toxicology, JCR 2024) (Corresponding author) NSTC 113-2314-B-038-084 and NSTC 113-2314-B-039-044
• C-C Chang, H-M Lao, S-C Fan, Y-H Tu, J-C Siew, K-C Ma, Y-H Lee, H-M Chiang, C-C Chang, T Y Juang *. Bioactive hyperbranched polymer dot combined laser-induced optical breakdown for accelerating wound repair and regeneration in a nude mice mode. Materials Advances 6(10):3185-3202 (2025) (S.C.I. Impact factor: 4.7. Subject Category: 207/462=44.8% in MATERIALS SCIENCE, MULTIDISCIPLINARY, JCR 2024)
• H-W Chiu, C-W Chu, C-Ca Huan, Z-C Chia, Y-L Wang, Y-H Lee*. Polystyrene microplastics induce hepatic lipid metabolism and energy disorder by upregulating the NR4A1-AMPK signaling pathway. Environmental Pollution 369, 125850 (2025). (S.C.I. Impact factor: 7.3. Subject Category: 46/374=12.3% in Environmental Sciences, JCR 2024) (Corresponding author) NSTC 113-2314-B-038-084 and NSTC 113-2314-B-039-044
• Y-H Cheng, H-I. Wu, Y-Y Chen, Y-H Lee, B-J Wang* and Y-J Wang*. Adverse outcome pathway-based approach to reveal the mechanisms of skin sensitization and long-term aging effects of chlorothalonil. Journal of Hazardous Materials 476, 135176 (2024). (S.C.I. Impact factor: 11.3. Subject Category: 19/374=5.1% in Environmental Sciences, JCR 2024)
• B-J Wang, Y-Y Chen, H-H Chang, R-J Chen, Y-J Wang* and Y-H Lee*. Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury. Particle and Fibre Toxicology. 21, 9 (2024). (S.C.I. Impact factor: 8.2. Subject Category: 5/106=4.7% in Toxicology, JCR 2024)  (Corresponding author) NSTC 112-2314-B-039-044, CMU112-S-50.
• *. Oxidative stress and potential effects of metal nanoparticles: a review of biocompatibility and toxicity concerns. Environmental Pollution 346, 123617 (2024) (S.C.I. Impact factor: 7.3. Subject Category: 46/374=12.3% in Environmental Sciences, JCR 2024)
• Y-L Wang^#, C C-Y Huang, C-M Zheng, W-C Liu, Y-H Lee^# and H-W Chiu*. Polystyrene microplastic-induced extracellular vesicles cause kidney-related effects in the crosstalk between tubular cells and fibroblasts. Ecotoxicology and Environmental Safety 273, 116098 (2024) (S.C.I. Impact factor: 6.1. Subject Category: 10/106=9.4% in Toxicology, JCR 2024) (co-First author)
• H-J Huang^#, Y-H Lee, L-C Sung, Y-J Chen, Y-J Chiu, H-W Chiu^# and C-M Zheng*. Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor. Computational and Structural Biotechnology Journal 21, 3490–3502 (2023) (S.C.I. Impact factor: 4.1. Subject Category: 104/319=32.6% in Biochemistry & Molecular Biology, JCR 2024) MOST 109-2314-B-038-078-MY3, MOST 110-2314-B-038-140, MOST 110-2314-B-039-018, MOST 110- 2314-B-038-075-MY3, MOST 111-2314-B-039-021, MOST 111-2314- B-038-154, MOST 111-2314-B-038-030, NSTC 112-2314-B-038-087 and NSTC 112-2314-B-039-044
• W-C Liu, H-W Chiu, C-L Chou, Y-J Chiu and Y-H Lee*. Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis. Environmental Pollution 318, 120871 (2023). (S.C.I. Impact factor: 7.3. Subject Category: 46/374=12.3% in Environmental Sciences, JCR 2024) (Corresponding author) MOST 110-2314-B-039-018; MOST 111-2314-B-039-021
• C-M Zheng, K-C Lu, Y-J Chen, C-Y Li, Y-H Lee* and H-W Chiu*. Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy. Biomedicine & Pharmacotherapy 154, 113565 (2022). (S.C.I. Impact factor: 7.5. Subject Category: 19/352=5.4% in Pharmacology & Pharmacy, JCR 2024) (Corresponding author) MOST 110-2314-B-039-018; MOST 111-2314-B-039-021
• Z-Y Chen, Y-C Yang, B-J Wang, F-Y Cheng, Y-L Lee, Y-H Lee* and Y-J Wang*. Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae. Ecotoxicology and Environmental Safety 243, 113967 (2022). (S.C.I. Impact factor: 6.1. Subject Category: 10/106=9.4% in Toxicology, JCR 2024) (Corresponding author) MOST 108-2314-B-039-061-MY3
• H-J Huang, Y-H Lee, C-L Chou, C-M Zheng*and H-W Chiu*. Investigation of potential descriptors of chemical compounds on prevention of nephrotoxicity via QSAR approach. Computational and Structural Biotechnology Journal 20,1876-1884 (2022). (S.C.I. Impact factor: 4.1. Subject Category: 104/319=32.6% in Biochemistry & Molecular Biology, JCR 2024). MOST 108-2314-B-039-061-MY3, MOST 109-2314-B-038-078-MY3, MOST 110-2314-B-038-140 and MOST 110-2314-B-038-075-MY3
• W-C Liu^#, H-C Chuang, C-L Chou, Y-H Lee, Y-J Chiu, Y-L Wang^# and H-W Chiu*. Cigarette smoke exposure increases glucose-6-phosphate dehydrogenase, autophagy, fibrosis and senescence in kidney cells in vitro and in vivo. Oxidative Medicine and Cellular Longevity 2022, 5696686 (2022). MOST 108-2314-B-039-061-MY3
• B-H Mao^#, Y-K Luo, B-J Wang, C-W Chen, F-Y Cheng, Y-H Lee^#, S-J Yan*, Y-J Wang*. Use of an In silico Knowledge Discovery Approach to Determine Mechanistic Studies of Silver Nanoparticles-induced Toxicity from In vitro to In vivo. Particle and Fibre Toxicology. 19, 6 (2022). (S.C.I. Impact factor: 8.2. Subject Category: 5/106=4.7% in Toxicology, JCR 2024)(co-First author)
• Y-Y Chen^#, Y-H Lee^#, B-J Wang, R-J Chen, Y-J Wang. Skin Damage Induced by Zinc Oxide Nanoparticles Combined with UVB is Mediated by Activating Cell Pyroptosis via the NLRP3 Inflammasome-Autophagy-Exosomal Pathway. Particle and Fibre Toxicology. 19, 2 (2022). (S.C.I. Impact factor: 8.2. Subject Category: 5/106=4.7% in Toxicology, JCR 2024)(co-First author) MOST 108-2314-B-039-061-MY3
• Y-L Wang^#, Y-H Lee, Y-H Hsu, I-J Chiu, C C-Y Huang, C-C Huang, Z-C Chia, C-P Lee, Y-F Lin^# and H-W Chiu*. The kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells HK-2 and male C57BL/6 mice. Environmental Health Perspectives 129(5), 57003 (2021). (S.C.I. Impact factor: 9.8. Subject Category: 3/106=2.8% in Toxicology, JCR 2024) MOST 108-2314-B-039-061-MY3
• Y-L Wang, C-M Zheng, Y-H Lee, Y-Y Cheng, Y-F Lin and H-W Chiu*. Micro- and nanosized substances cause different autophagy-related responses. International Journal of Molecular Sciences 22, 4787 (2021). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024) MOST 108-2314-B-039-061-MY3
• H-J Huang, Y-H Lee, Y-H Hsu, C-T Liao, Y-F Lin* and H-W Chiu*. Current strategies in assessment of nanotoxicity: Alternatives to in vivo animal testing. International Journal of Molecular Sciences 22, 4216 (2021). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024) MOST108-2314-B-039-061-MY3
• Y-H Hsu^#, C-M Zheng, C-L Chou, Y-J Chen, Y-H Lee^#, Y-F Lin*, H-W Chiu*. Therapeutic effect of endothelin-converting enzyme inhibitor on chronic kidney disease through the inhibition of endoplasmic reticulum stress and the NLRP3 inflammasome. Biomedicines 9, 398 (2021). (S.C.I. Impact factor: 3.9. Subject Category: 88/352=25.0% in Pharmacology & Pharmacy, JCR 2024) (co-First author) MOST 108-2314-B-039-061-MY3
• R‑J Chen^#, C-C Huang, R Pranata, Y‑H Lee^#, Y-Y Chen, Y-H Wu*, Y‑J Wang*. Modulation of innate immune toxicity by silver nanoparticle exposure and the preventive effects of pterostilbene.International Journal of Molecular Sciences 22, 2536 (2021). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024) (co-First author) MOST 108-2314-B-039-061-MY3
• R‑J Chen^#, Y‑H Lee^#, T‑H Chen, Y‑Y Chen, Y‑L Yeh, C‑P Chang, C‑C Huang, H-R Guo*, Y‑J Wang*. Carbon monoxide‑triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes. Archives of Toxicology 95(4):1141-1159 (2021). (S.C.I. Impact factor: 4.8. Subject Category: 14/106=13.2% in Toxicology, JCR 2023). (co-First author) MOST 108-2314-B-039-061-MY3
• C-M Zheng^#, Y-H Lee, I-J Chiu, Y-J Chiu, L-C Sung, Y-H Hsu and H-W Chiu*. Nicotine Causes Nephrotoxicity through the Induction of NLRP6 Inflammasome and Alpha7 Nicotinic Acetylcholine Receptor. Toxics 8(4), 92 (2020). (S.C.I. Impact factor: 4.1. Subject Category: 23/106=21.7% in Toxicology, JCR 2024). MOST 108-2314-B-039-061-MY3
• Y-H Hsu^#, I-J Chiu, Y-F Lin, Y-J Chen, Y-H Lee^# and H-W Chiu*. Lactoferrin contributes a renoprotective effect in acute kidney injury and early renal fibrosis. Pharmaceutics 12(5), 434 (2020). (S.C.I. Impact factor: 5.5. Subject Category: 34/352=9.7% in Pharmacology & Pharmacy, JCR 2024). (co-First author) MOST 108-2314-B-039-061-MY3.  
• Z-Y Chen, N-J Li, F-Y Cheng, J-F Hsueh, C-C Huang, F-I Lu, T-F Fu, S-J Yan, Y-H Lee* and Y-J Wang*. The effect of chorion on size-dependent developmental toxicity and underlying mechanisms of amine-modified silver nanoparticles in zebrafish embryo.International Journal of Molecular Sciences 21, 2864 (2020). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024) (Corresponding author) MOST 108-2314-B-039-061-MY3.
• R-J Chen, Y-Y Chen, M-Y Liao, Y-H Lee, Z-Y Chen, S-J Yan, Y-L Yeh, Y-L Lee, L-X Yang, Y-H Wu *and Ying-Jan Wang *. The current understanding of autophagy in nanomaterials toxicity and its implementation in safety assessment related alternative testing strategy. International Journal of Molecular Sciences 21(7), 2387 (2020) (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024)
• Y-L Wang, Y-H Lee, I-J Chiu, Y-F Lin* and H-W Chiu*. Potent impact of plastic nanomaterials and micromaterials on the food chain and human health. International Journal of Molecular Sciences 21(5), 1727 (2020). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024)
• F-Y Cheng#, Y-H Lee, Y-H Hsu, I-J Chiu, Y-J Chiu, Y-F Lin# and H-W Chiu*. Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1. Aging (Albany NY) 12;11(21):9875-9892 (2019). (S.C.I. Impact factor: 3.9. Subject Category: 24/74=32.4% in Geriatrics & Gerontology, JCR 2024)
• Y-H Hsu^#, H-C Chuang, Y-H Lee, Y-F Lin, Y-J Chiu, Y-L Wang^#, M-S Wu*and H-W Chiu*. Induction of fibrosis and autophagy in kidney cells by vinyl chloride. Cells 8, 601 (2019). (S.C.I. Impact factor: 5.2. Subject Category: 59/204=28.9% in Cell Biology, JCR 2024)
• Y-H Lee^#, Y-Y Chen^#, Y-L Yeh, Y-J Wang* and R-J Chen*. Stilbene Compounds Inhibit Tumor Growth by the Induction of Cellular Senescence and the Inhibition of Telomerase Activity. International Journal of Molecular Sciences 20: 2716 (2019). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024) (co-First author)
• Y-H Hsu^#, H-C Chuang, Y-H Lee, Y-F Lin, Y-J Chen, T-C Hsiao, M-Y Wu^# and H-W Chiu*. Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo. Free Radical Biology & Medicine 135: 235-244 (2019) (S.C.I. Impact factor: 8.2. Subject Category: 14/191=7.3% in Endocrinology & Metabolism, JCR 2024)
• B-J Wang, H-W Chiu, Y-Lin Lee, C-Yi Li, Y-J Wang* and Y-H Lee*. Pterostilbene attenuates hexavalent chromium-induced allergic contact dermatitis by preventing cell apoptosis and inhibiting IL-1β-related NLRP3 inflammasome activation. Journal of Clinical Medicine 7(12), 489 (2018) (S.C.I. Impact factor: 2.9. Subject Category: 65/332=19.6% in Medicine, General & Internal, JCR 2024). MOST 107-2314-B-006-007. (Corresponding author)
• R-J Chen, H-C Kuo, L-H Cheng, Y-H Lee, W-T Chang, B-J Wang, Y-J Wang and H-C Cheng. Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer.International Journal of Molecular Sciences 19(1), 287 (2018). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024)
• Y-F Lin, Y-H Lee, Y-H Hsu, Y-J Chen, Y-F Lin, F-Y Cheng and H-W Chiu. Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease. Nanomedicine 12(22):2741-2756 (2017) (S.C.I. Impact factor: 3.9. Subject Category: 54/177=30.5% in Biotechnology & Applied Microbiology, JCR 2024)
• Y-H Lee, C-Y Fang, H-W Chiu, F-Y Cheng, J-C Tsai, C-W Chen and Y-J Wang. Endoplasmic reticulum stress-triggered autophagy and lysosomal dysfunction contribute to the cytotoxicity of amine-modified silver nanoparticles in NIH 3T3 cells. Journal of Biomedical Nanotechnology 13: 778–794 (2017) (First author)
• R-J Chen, Y-H Lee^#, Y-L Yeh, W-S Wu, C-T Ho, C-Y Li, Y-J Wang and B-J Wang. Autophagy-inducing Effect of Pterostilbene: a Prospective Therapeutic/Preventive Option for Skin Diseases. J Food Drug Anal. 25:125-133 (2017) (S.C.I. Impact factor: 2.6. Subject Category: 85/173=49.1% in Food Science and Technology, JCR 2023) (co-First author)
• 楊翊羣、李宥萱、陳綉敏、毛彬旭、陳春萬、王應然。奈米微粒危害分級管理適用性之探討-以奈米氧化鋅為例。勞動及職業安全衛生研究季刊，民國106年9月第25卷第3期第143-227頁。
• R-J Chen, Y-H Lee^#, Y-L Yeh, Y-J Wang and B-J Wang. The Roles of Autophagy and the Inflammasome during Environmental Stress-Triggered Skin Inflammation. International Journal of Molecular Sciences 17(12):2063 (2016). (S.C.I. Impact factor: 4.9. Subject Category: 72/319=22.6% in Biochemistry & Molecular Biology, JCR 2024) (co-First author)
• Y-F Lin, I-J Chiu, F-Y Cheng, Y-H Lee, Y-J Wang, Y-H Hsu and H-W Chiu. The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo. Particle and Fibre Toxicology. 13:52 (2016). (S.C.I. Impact factor: 8.2. Subject Category: 5/106=4.7% in Toxicology, JCR 2024)
• 李宥萱、方春詠、陳春萬、王應然。奈米微粒危害測試技術與生物毒性指標之探討。勞動及職業安全衛生研究季刊，民國105年9月第24卷第3期第330-342頁。
• H-M Chen, Y-H Lee^#, Y-J Wang. ROS-Triggered Signaling Pathways Involved in the Cytotoxicity and Tumor Promotion Effects of Pentachlorophenol and Tetrachlorohydroquinone. Chemical Research in Toxicology 28(3):339-50 (2015). (S.C.I. Impact factor:3.7 Subject Category: 29/72=40.2% in Chemistry, Medicinal, JCR 2023) (co-First author)
• H-W Chiu, T Xia, Y-H Lee,C-W Chen,J-C Tsai, and Y-J Wang *. Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress. Nanoscale. 7(2):736-462 (2015) (S.C.I. Impact factor: 5.1. Subject Category: 45/187=24.1% in Physics, Applied, JCR 2024)
• Y-H Lee, F-Y Cheng, H-W Chiu, J-C Tsai, C-Y Fang, C-W Chen and Y-J Wang. Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts. Biomaterials 35: 4706-4715 (2014) (S.C.I. Impact factor: 12.9. Subject Category: 5/124=4.0% in Engineering, Biomedical, JCR 2024) NSC 102-2314-B-006-034 (First author)
• J-W Guo, Y-H Lee, H-W Huang, M-C Tzou, Y-J Wang, J-C Tsai. Development of Taiwan’s strategies for regulating nanotechnology-based pharmaceuticals harmonized with international considerations. International Journal of Nanomedicine 9:4773-4783 (2014) (S.C.I. Impact factor: 6.6. Subject Category: 20/354 =5.6% in Pharmacology & Pharmacy, JCR 2023)
• Y-H Lee, S-B Su, C-C Huang, H-M Sheu, J-C Tsai, C-H Lin, Y-J Wang, B-J Wang. N-acetylcysteine attenuates hexavalent chromium-induced hypersensitivity through inhibition of cell death, ROS-related signaling and cytokine expression. PLoS ONE. 9: e108317 (2014) (S.C.I. Impact factor: 2.6. Subject Category: 44/135 =32.6% in Multidisciplinary Sciences, JCR 2024) NSC-102-2314-B-006-034 (First author)
• H-M Chen, Y-H Lee, R-J Chen, H-W Chiu, B-J Wangand Y-J Wang. The immunotoxic effects of dual exposure to PCP and TCDD. Chemico-Biological Interactions 206:166-174 (2013) (S.C.I. Impact factor: 5.4. Subject Category: 38/352=10.8% in Pharmacology & Pharmacy, JCR 2024) NSC 101-2314-B-006-050 (co-First author)
• N-P Foo, S-H Lin, Y-H Lee, M-J Wu, Y-J Wang*. α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β. Toxicology 282: 39-46 (2011) (S.C.I. Impact factor: 4.8. Subject Category: 14/106=13.2% in Toxicology, JCR 2023) NSC 98-2314-B-006-034-MY2
• B-J Wang, H-M Sheu, Y-Lg Guo, Y-H Lee, C-S Lai, M-H Pan, Y- J Wang*. Hexavalent chromium-induced ROS formation, Akt, NF-κB, and MAPK activation, and TNF-α and IL-1α production in keratinocytes. Toxicology Letters 198: 216-224 (2010) (S.C.I. Impact factor: 2.9. Subject Category: 49/106=46.2% in Toxicology, JCR 2023) NSC 98-2314-B-006-034-MY2
• B-J Wang, Y-L Guo, H-Y Chang, H-M Sheu, M-H Pan, Y-H Lee and Y-J Wang*. N-acetylcysteine inhibits chromium hypersensitivity in coadjuvant chromium-sensitized albino guinea pigs by suppressing the effects of reactive oxygen species. Experimental Dermatology 19: e191-e200 (2010) (S.C.I. Impact factor: 3.5. Subject Category: 20/94 =21.2% in Dermatology, JCR 2023) NSC-95-2314-B-006-095-MY3

B. 研討會論文

• , Yu-Hsuan Lee. CSF2-Driven Inflammasome Activation and Senescence Mediate Particulate Matter–Induced Renal Injury. The 15th National Conference in Toxicology (NCT15), Bangkok, Thailand, Sep. 3-4, 2025.

• Particulate matter promotes the development of atopic dermatitis by inhibiting TREX1 and activating the inflammasome pathway. The 49th FEBS Congress. Istanbul, Turkey, July 5-9, 2025.

• Particulate matter exacerbates kidney damage by increasing the CSF2, inflammasomes, and senescence. The Asian Pacific Congress of Nephrology 2024 in conjunction with the 44^th Annual Meeting of the Korean Society of Nephrology. Coex, Seoul, Korea. June 13-16, 2024.

• Yu-Hsuan Lee. Particulate Matter (PM) causes skin barrier dysfunction : The exacerbation of on Atopic Dermatitis. The 38^th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. 23-24 Mar, 2024.

• 2023 年10月29-31 日。

• Naringin regulated macrophage differentiation to promote wound healing by affecting the expression of CMPK2. 10^th International Congress of Asian Society of Toxicology (ASIATOX-X). NTUH International Convention Center, Taipei, Taiwan. July 17-20, 2023.

• Yu-Hsuan Huang, Hui-Wen Chiu and Yu-Hsuan Lee. The role of autophagy regulated-NLRP3 inflammasome inactivation in the therapy of alcoholic liver disease. 9^th International Congress of Asian Society of Toxicology (ASIATOX-IX). Hangzhou, Zhejiang Province, China (Online). October 20-23, 2021.

• Yuh-Feng Lin, Yu-Hsuan Lee and Hui-Wen Chiu. Crosstalk between endoplasmic reticulum stress and autophagy in kidney diseases. International Society for Extracellular Vesicles (ISEV) Annual Meeting 2019. Kyoto, Japan, 24-28 April 2019.

• Yi-Kai Lou, Ying-Jan Wang, Yu-Hsuan Lee. Hazard estimation of silver nanoparticles in different cellular models using methods of knowledge discovery from data. The 43^rd FEBS 2018 Congress. Prague, Czech Republic, 7-12 July, 2018.

• Yu-Hsuan Lee, Yung-Lin Li, Bour-Jr Wang and Ying-Jan Wang. Interference in apoptosis and endoplasmic reticulum stress by pterostilbene assists autophagy in regulating an interleukin-1β in the hexavalent chromium-induced allergic contact dermatitis. EMBO Conference- Structure and function of the endoplasmic reticulum. Girona, Spain, 23-27 October, 2016.

• Yu-Hsuan Lee, Chun-Wan Chenand Ying-Jan Wang. Induction of Autophagy and Cytotoxicity by Different Sized Silver Nanoparticles in NIH 3T3 Cells. The 9th IEEE international Conference on Nano/Molecular Medicine and Engineering. Waikiki Beach, Hhawaii, USA, 15-18 November, 2015.

• Yu-Hsuan Lee, Bour-Jr Wang, and Ying- Jan Wang. N-acetylcysteine inhibits hexavalent chromium-induced cell death and TNF-α and IL-1α expression, thereby preventing the development of chromium hypersensitivity. Cell Death Mechanisms at the Interface of Health and Disease (Gordon Research Conferences). West Dover, VT, USA, 8-13 June, 2014.

• Yu-Hsuan Lee, Chun-Wan Chen, Jui-Chen Tsai, Ying-Jan Wanga. Study on the contributing factors of cytotoxicity and adverse index of silver nanoparticle by using mammalian cell lines. 4th International Nanomedicine Conference. Sydney, Australia, 1-3 July, 2013.

• Yu-Hsuan Lee, Yung-Lin Li and Ying-Jan Wang. The mechanism of antioxidants suppressed the hexavalent chromium-induced allergic contact dermatitis. 3rd EMBO Conference Series on Cellular Signaling &Molecular Medicine. Dubrovnik, Cavtat, 25 – 29 May, 2012.

• Yu-Hsuan Lee, Sheng-Yow Ho, Wen-Hung Fang and Ying-Jan Wang. The possible chemopreventive effects of Monascus on prostate related disease and the enhanced therapeutic potency for prostate cancer combined with irradiation. Warszawa, Poland, 28 August – 1 September, 2011.